Autoimmune thrombotic thrombocytopenic purpura associated with HHV8-related Multicentric Castleman disease

Multicentric Castleman's Disease, Associated with Idiopathic Thrombocytopenic Purpura

The most common cause of a neck mass in young adults is hyperplastic lymphadenopathy consequent to infection and inflammation. Castleman's disease (CD), an unusual benign lymphoproliferative disorder, infrequently causes neck masses. It occurs in unicentric (UCD) and multicentric (MCD) forms and is associated with human immunodeficiency virus (HIV), human herpes virus 8 (HHV-8), and Kaposi's sa...

Pregnancy-associated thrombotic thrombocytopenic purpura.

Thrombocytopenia during pregnancy is a common diagnostic and management problem. Several differential diagnosis must be considered including manifestations of thrombotic thrombocytopenic purpura (TTP). We report here on a case of a 21-year-old pregnant woman who presented initially severe thrombocytopenia (8 Gpt/l) in the 20(th)+1 week of gestation. The patient had an antibody against ADAMTS13,...

Ticagrelor-associated thrombotic thrombocytopenic purpura

Thrombotic thrombocytopenic purpura associated with cerebral SLE.

A case of thrombotic thrombocytopenic purpura in a patient with a recent flare of cerebral lupus is presented. The patient presented with neurologic symptoms, pyrexia, thrombocytopenia and leucocytosis. Following initial investigation, imaging of brain and negative microbiology, a diagnosis of cerebral lupus was made and appropriately treated. After a stable period oftwo weeks, deterioration in...

Thrombotic thrombocytopenic purpura associated with anti-glomerular basement membrane disease.

Goodpasture's disease is associated with circulating anti-glomerular basement membrane (anti-GBM) antibodies. Thrombotic thrombocytopenic purpura (TTP) is a disease related to platelet clumping and microthrombosis in the circulation. We report an unusual case where both entities coexist in the same patient. The patient was a 43-year-old Caucasian male, with a recent history of inhalational hydr...